From the Civil War to the New Deal, America's move towards federalism was almost systematically completed as if by some master plan.
In 1913, one of the key constitutional amendments (17th) was ratified, taking the election of senators from the state legislatures and giving it to the population at large -- a move still seen by many as an affront to states' rights.
Only one of the Founding Fathers, James Wilson, was in favor of the popular election of senators, highlighting the fact that the Senate was "as it was supposed to be" in the eyes of the Founders.