More than $50 million was spent on Georgia's Sixth Congressional District special election.
For Democrats, a win would have been a sign that the Trump resistance is translating into tangible electoral gains.
For Republicans, it is a sign that despite the harsh media rhetoric towards the President and their party, they continue to win congressional seats.
The timing of Karen Handel's win could also impact the national conversation over health care, as Senate Republicans are about to roll out their repeal of Obamacare this week.
Democrats will spin Jon Ossoff's loss by saying that it shouldn't have been this close. That a district long dominated by Republicans, in particular Newt Gingrich, should never have resulted in a narrow win, and thus showing a weakness in the president and the Republican Party.
Republicans will counter that despite tens of millions of dollars from special interests, Ossoff couldn't cash in.
Ossoff, a 30-year-old investigative filmmaker, quickly became a rising Democratic star. With a carefully calibrated message, Ossoff shattered fundraising records as he appealed to liberals from coast to coast who have been infuriated by Trump and GOP voters frustrated at Washington gridlock.